In diseases of the brain, such as Alzheimer’s and Parkinson’s, the neurons fail to communicate correctly with each other. As Bonn-based researchers of the German Center for Neurodegenerative Diseases (DZNE) now report in the journal “Neuron“, these connectivity problems can be ascribed to alterations in the structure of the nerve cells. For their study, the scientists investigated diseased nerve cells using high precision methods and subsequently simulated their electrical properties on the computer.
The researchers, at Washington University School of Medicine in St. Louis, demonstrated that these converted cells survived at least six months after injection into the brains of mice and behaved similarly to native cells in the brain.
The link between a protein typically associated with Alzheimer's disease and its impact on memory and cognition may not be as clear as once thought, according to a new study from the University of Wisconsin-Madison's Waisman Center. The findings are revealing more information about the earliest stages of the neurodegenerative disease.