A new cell type is implicated in epilepsy caused by traumatic brain injury

A new study in mice identifies increased levels of a specific neurotransmitter as a contributing factor connecting traumatic brain injury (TBI) to post-traumatic epilepsy. The findings suggest that damage to brain cells called interneurons disrupts neurotransmitter levels and plays a role in the development of epilepsy after a traumatic brain injury.

Detecting, Testing, Treating Rare Diseases: Technology Delivers New Era of Personalization

A team of researchers from the National Institutes of Health, Emory University and Cedars-Sinai – specialists in identifying and treating very rare diseases – used three innovative tools to detect a previously unknown gene mutation, test potential therapies in the lab, and initiate personalized drug treatment for a boy with a lifelong history of uncontrollable seizures that caused significant impact on his cognitive and social development.

The Brain Observatory

The Brain Observatory was founded by Dr. Jacopo Annese at the University of California, San Diego in 2005. After receiving the postmortem brain of H.M. for examination the Brain Observatory came to house the Digital Brain Project Library.

The Neuro

The Montreal Neurological Institute and Hospital (the Neuro) is an academic medical center dedicated to neuroscience. The Neuro has been recognized for its epilepsy research and treatment.

New technology for the detection of genetic abnormalities which lead to serious epilepsy

A European consortium of epilepsy researchers has reported the discovery of a new gene involved in severe childhood epilepsy. Using a novel combination of technologies, including trio exome sequencing of patient/parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome – a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

Training your brain using neurofeedback

Magnetoencephalography (MEG) can be used as a potential therapeutic tool to control and train specific targeted brain regions. This advanced brain-imaging technology has important clinical applications for numerous neurological and neuropsychiatric conditions.

How metabolism and brain activity are linked

A new study by scientists at McGill University and the University of Zurich shows a direct link between metabolism in brain cells and their ability to signal information. The research may explain why the seizures of many epilepsy patients can be controlled by a specially formulated diet.

Scientists discover two proteins that control chandelier cell architecture

Chandelier cells are neurons that use their unique shape to act like master circuit breakers in the brain’s cerebral cortex. These cells have dozens, often hundreds, of branching axonal projections – output channels from the cell body of the neuron – that lend the full structure of a chandelier-like appearance. Each of those projections extends to a nearby excitatory neuron. The unique structure allows just one inhibitory chandelier cell to block or modify the output of literally hundreds of other cells at one time.