{"id":34,"date":"2023-08-10T15:20:15","date_gmt":"2023-08-10T15:20:15","guid":{"rendered":"https:\/\/pediatricbrainfoundation.org\/archive\/disease-directory\/"},"modified":"2023-08-10T15:21:00","modified_gmt":"2023-08-10T15:21:00","slug":"disease-directory","status":"publish","type":"page","link":"https:\/\/pediatricbrainfoundation.org\/archive\/disease-directory\/","title":{"rendered":"Disease Directory"},"content":{"rendered":"<div class=\"row-fluid\">\n<section class=\"content-top span12\">\n      <a id=\"main-content\"><\/a><\/p>\n<h1 class=\"page-header\">Get Educated<\/h1>\n<div class=\"secondary-nav\">\n<div class=\"region region-secondary-navigation\">\n<section id=\"block-menu-block-1\" class=\"block block-menu-block clearfix\">\n<div class=\"section-in\">\n<div class=\"section-inn\">\n<div class=\"section-innn\">\n<div class=\"menu-block-wrapper menu-block-1 menu-name-main-menu parent-mlid-0 menu-level-2\">\n<ul class=\"menu nav\">\n<li class=\"first leaf active-trail active menu-mlid-479 active\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory\/\" class=\"active-trail active\">Disease Directory<\/a><\/li>\n<li class=\"last leaf menu-mlid-484\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/glossary\/\">Glossary<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p> <!-- \/.block -->\n  <\/div>\n<\/p><\/div>\n<p>  <!-- \/#secondary-navigation --><\/p>\n<div class=\"region region-content-top\">\n<section id=\"block-views-exp-disorder-disorder\" class=\"block block-views clearfix\">\n<div class=\"section-in\">\n<div class=\"section-inn\">\n<div class=\"section-innn\">\n<form action=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory\/\" method=\"get\" id=\"views-exposed-form-disorder-disorder\" accept-charset=\"UTF-8\">\n<div>\n<div class=\"views-exposed-form\">\n<div class=\"views-exposed-widgets clearfix\">\n<div id=\"edit-combine-wrapper\" class=\"views-exposed-widget views-widget-filter-combine row-fluid\">\n                  <label for=\"edit-combine\" class=\"span3\"><br \/>\n            Search by Keyword          <\/label><\/p>\n<div class=\"views-widget span9\">\n<div class=\"control-group form-type-textfield form-item-combine form-item\">\n<div class=\"controls\"> <input type=\"text\" id=\"edit-combine\" name=\"combine\" value=\"\" size=\"30\" maxlength=\"128\" class=\"form-text\"\/>\n<\/div>\n<\/div><\/div>\n<\/p><\/div>\n<div class=\"views-exposed-widget views-submit-button element-invisible\">\n      <button class=\"btn btn-primary form-submit\" id=\"edit-submit-disorder\" name=\"\" value=\"Search\" type=\"submit\">Search<\/button>\n    <\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<\/form>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p> <!-- \/.block -->\n  <\/div>\n<div id=\"glossary-nav\">\n          <a href=\"# \" class=\"letter_link\"> <\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#a\" class=\"letter_link\">A<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#c\" class=\"letter_link\">C<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#e\" class=\"letter_link\">E<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#f\" class=\"letter_link\">F<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#h\" class=\"letter_link\">H<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#m\" class=\"letter_link\">M<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#p\" class=\"letter_link\">P<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#s\" class=\"letter_link\">S<\/a>&nbsp;&nbsp;&nbsp; | &nbsp;&nbsp;&nbsp;<a href=\"#t\" class=\"letter_link\">T<\/a>        <\/div>\n<\/section><\/div>\n<div class=\"row-fluid\">\n<section class=\"main-content span9\">\n<section id=\"block-system-main\" class=\"block-system block-page-content clearfix\">\n<div class=\"section-in\">\n<div class=\"section-inn\">\n<div class=\"section-innn\">\n<div class=\"view view-disorder view-id-disorder view-display-id-disorder view-dom-id-c12da8fc14b622482267a34765eb71de\">\n<div class=\"view-content\">\n<div class=\"item-list\">        <a name=\" \"><\/a><\/p>\n<h4 class=\"letter\">\n           <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/looking-something-specific\/\"> Looking for something specific?<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">Don&#8217;t see a disease definition that you are looking for? Do not hesitate to contact us directly by using our <a href=\"http:\/\/cnsfoundation.org\/contact-us\">webform<\/a> or by sending an email to <a href=\"mailto:info@pediatricbrainfoundation.org\">info@pediatricbrainfoundation.org<\/a>\u00a0to get it added.\u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/looking-something-specific\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"a\"><\/a><\/p>\n<h4 class=\"letter\">\n      A    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/acute-disseminated-encephalomyelitis-adem\/\">Acute Disseminated Encephalomyelitis (ADEM)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">uh-kyoot   dih-sem-uh-neyt-ed   en-sef-uh-loh-mahy-uh-lahy-tis<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Acute Disseminated Encephalomyelitis (ADEM) is a demylelinating diseases, most commonly occurring after an acute bacterial or viral infection or, less commonly, following the vaccination for measles, mumps, and rubella. \u00a0An autoimmune attack upon the nervous system causes widespread inflammation in the brain and spinal cord that damages <a href=\"http:\/\/cnsfoundation.org\/educate\/term\/myelin\" target=\"_blank\" rel=\"noopener\">myelin<\/a>. <span style=\"line-height: 1.45em;\">\u00a0<\/span><\/p>\n<p class=\"tkgyxz44ddvou8s4e\">\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/acute-disseminated-encephalomyelitis-adem\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/alexander-disease\/\">Alexander Disease<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">al-ig-zahn-der   dih-zeez<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Alexander disease is a progressive, genetic, and fatal brain disorder that most commonly occurs in children. \u00a0It leads to death usually within the first decade.\u00a0<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">Alexander disease is classified as one of the leukodystrophies, or white matter diseases, causing abnormalities in myelin. \u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/alexander-disease\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-3 views-row-odd\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/angelman-syndrome\/\">Angelman Syndrome<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">eyn-juhl-man   sin-drohm<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Angelman Syndrome is a genetic disorder that causes developmental delay and neurological problems.\u00a0 Angelman Syndrome is due in most cases to a chromosome\u00a0deficiency\u00a0involving loss of material from chromosome region 15q12. The deficient chromosome is passed on from the mother.<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">Deletion of chromosome region 15q12 causes both Angelman Syndrome and a totally different disorder called Prader-Willi Syndrome.\u00a0 While the deleted chromosome is of maternal origin in Angelman Syndrome, it is the paternal chromosome that is partially deleted in the Prader-Willi Syndrome.\u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/angelman-syndrome\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-4 views-row-even\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/ataxia-telangiectasia-t\/\">Ataxia-telangiectasia (A-T)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">uh-tak-see-uh   tel-an-je-ek-ta-zha<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Ataxia-telangiectasia (A-T) is a rare, progressive neurodegenerative genetic disease that becomes evident in early childhood, usually in the first few years of life. \u00a0A-T causes degeneration in the part of the brain that controls motor movements and speech. \u00a0Some children will develop normally the first 3-5 years before regressing and exhibiting difficulty in walking or standing without support.<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/ataxia-telangiectasia-t\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-5 views-row-odd\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/autism\/\">Autism<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">aw-tiz-uhm<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Autism is a developmental disorder that appears in the first 3 years of life, and affects the brain&#8217;s normal development of social and communication skills. Autism is a physical condition linked to abnormal biology and chemistry in the brain. The exact causes of these abnormalities remain unknown, but this is a very active area of research and there are probably a combination of factors that lead to autism.<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/autism\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-6 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"c\"><\/a><\/p>\n<h4 class=\"letter\">\n      C    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/cerebral-palsy-cp\/\">Cerebral Palsy (CP)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">suh-ree-bruhl   pawl-zee<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\"><span style=\"line-height: 1.45em;\">Cerebral Palsy, CP for short, refers to a group of disorders that affect different motor functions resulting in physical disabilities limiting body movement and muscle coordination.\u00a0 CP is non-progressive, which means the physical disabilities will not get worse over time.\u00a0 While CP affects muscle control and body movement, the root of the problem is not with the muscles or nerves themselves.<\/span><\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/cerebral-palsy-cp\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"e\"><\/a><\/p>\n<h4 class=\"letter\">\n      E    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/epilepsy\/\">Epilepsy<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">ep-uh-lep-see<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Epilepsy is a spectrum of brain disorders ranging from very mild or benign to disabling and life-threatening. \u00a0<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">Epilepsy occurs when nerve cells in the brain fire electrical impulses at a rate of up to four times higher than normal. This causes a sort of electrical storm in the brain, known as a seizure. A pattern of repeated seizures (two or more) is referred to as epilepsy. Having a single seizure as the result of a high fever (called febrile seizure) or head injury does not necessarily mean that a person has epilepsy.\u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/epilepsy\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"f\"><\/a><\/p>\n<h4 class=\"letter\">\n      F    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/fetal-alcohol-syndrome-fas\/\">Fetal Alcohol Syndrome (FAS)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">feet-l   al-kuh-hawl   sin-drohm<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Fetal Alcohol Syndrome (FAS) is the sum total of the damage done to the child before birth as a result of the mother drinking alcohol during pregnancy.\u00a0<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">No amount of alcohol has been proven to be safe during pregnancy. Women who are or may become pregnant are therefore strongly advised to avoid alcohol. Even light drinking (less than three alcoholic drinks per week) during the first trimester of pregnancy has been associated with memory and learning problems.\u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/fetal-alcohol-syndrome-fas\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"h\"><\/a><\/p>\n<h4 class=\"letter\">\n      H    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/hydranencephaly\/\">Hydranencephaly<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">Hi-dran-en-sef-uh-lee<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">Hydranencephaly (or hydroanencephaly)\u00a0is a\u00a0congenital condition in which the brain&#8217;s cerebral hemispheres are absent to varying degrees and the resulting empty cranial cavity is filled with cerebrospinal fluid. Hydranencephaly is one of several types of cephalic disorders. These disorders derive from either damage to, or abnormal development of, the fetal nervous system in the earliest stages of development in utero.<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/hydranencephaly\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"m\"><\/a><\/p>\n<h4 class=\"letter\">\n      M    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/med23-gene-defect\/\">MED23 Gene Defect<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">med   twen-tee-three   jeen   dee-fekt<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">MED23 gene defect, also known as autosomal recessive nonsyndromic mental retardation-18, is a genetic neurological condition characterized by intellectual delays.\u00a0<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">It is autosomal and recessive, meaning that both parents carry some mutation on the MED23 gene and have a 25% chance of passing this gene onto their children.\u00a0<\/p>\n<p class=\"tkgyxz44ddvou8s4e\">There are two families known to exist worldwide- one in Algeria where five siblings are affected, and a pair of brothers in the United States.<\/p>\n<p><br class=\"tkgyxz44ddvou8s4e\"\/><\/div>\n<\/p><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/med23-gene-defect\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"p\"><\/a><\/p>\n<h4 class=\"letter\">\n      P    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/pitt-hopkins-syndrome-pths\/\">Pitt Hopkins Syndrome (PTHS)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">pit hop-kinz   sin-drohm<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Pitt Hopkins Syndrome (PTHS) is a rare genetic disorder resulting from a mutation of the TCF4 gene or a deletion in the region of the 18th chromosome where the TCF4 gene is located. \u00a0TCF4 is a transcription factor, so mutations or deletions in this region disrupt the body&#8217;s ability to carry out normal nervous system development and function resulting in developmental delay and intellectual disability. \u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/pitt-hopkins-syndrome-pths\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"s\"><\/a><\/p>\n<h4 class=\"letter\">\n      S    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/sanfilippo-syndrome-mps-iii\/\">Sanfilippo Syndrome (MPS III)<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">sahn-fil-ee-poh   sin-drohm<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Sanfilippo Syndrome is the most common disorder of mucopolysaccharide metabolism and also known as <i>Mucopolysaccharidosis Type III (MPS III)<\/i>.<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/sanfilippo-syndrome-mps-iii\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul>\n<p>      <a name=\"t\"><\/a><\/p>\n<h4 class=\"letter\">\n      T    <\/h4>\n<ul>\n<li class=\"views-row views-row-1 views-row-odd views-row-first\">\n<div class=\"views-field views-field-title\">        <span class=\"field-content\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/traumatic-brain-injury\/\">Traumatic Brain Injury<\/a><\/span>  <\/div>\n<div class=\"views-field views-field-field-phonetic-spelling\">        <em class=\"field-content\">traw-mat-ik   breyn   in-juh-ree<\/em>  <\/div>\n<div class=\"views-field views-field-field-disorder-what-it-is\">\n<div class=\"field-content\">\n<p class=\"tkgyxz44ddvou8s4e\">\n<p class=\"tkgyxz44ddvou8s4e\">Traumatic brain injury (TBI), or intracranial injury, is an acquired condition that occurs after a sudden and traumatic blow to the head. \u00a0The force of impact does not necessarily need to be severe to be traumatic and cause significant injury. Some TBIs are considered penetrating injures, when an object pierces the skull and fragments enter the brain directly. In addition to direct impact injuries, when the head collides directly with an object, TBI can be caused by sudden acceleration (or deceleration), causing the brain to bounce inside the skull. \u00a0<\/p>\n<\/div><\/div>\n<div class=\"views-field views-field-view-node\">        <span class=\"field-content more\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/traumatic-brain-injury\/\">Read more &rarr;<\/a><\/span>  <\/div>\n<\/li>\n<li class=\"views-row views-row-2 views-row-even views-row-last\">\n<div class=\"top-link\"><a href=\"#skip-link\">^ Back to top<\/a><\/div>\n<\/li>\n<\/ul><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p> <!-- \/.block --><br \/>\n      <\/section>\n<aside class=\"span3 hidden-phone\" role=\"complementary\">\n<div class=\"region region-sidebar-second\">\n<section id=\"block-cns-helper-search-disease-c\" class=\"block block-cns-helper clearfix\">\n<div class=\"section-in\">\n<div class=\"section-inn\">\n<div class=\"section-innn\">\n<h4 class=\"block-title clearfix\">Common Searches<\/h4>\n<div class=\"item-list\">\n<ul>\n<li class=\"first\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory-keyword-taysachs\/\" class=\"active\">Tay sachs<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory-keyword-neuroblastoma\/\" class=\"active\">Neuroblastoma<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory-keyword-hypotoniccerebralpalsy\/\" class=\"active\">Hypotonic cerebral palsy<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory-keyword-meningitis\/\" class=\"active\">Meningitis<\/a><\/li>\n<li class=\"last\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disease-directory-keyword-hypotonia\/\" class=\"active\">Hypotonia<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p> <!-- \/.block --><\/p>\n<section id=\"block-cns-helper-entity-node-disorder-d\" class=\"block block-cns-helper clearfix\">\n<div class=\"section-in\">\n<div class=\"section-inn\">\n<div class=\"section-innn\">\n<h4 class=\"block-title clearfix\">Recently Viewed<\/h4>\n<div class=\"item-list\">\n<ul>\n<li class=\"first\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/hydranencephaly\/\">Hydranencephaly<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/ataxia-telangiectasia-t\/\">Ataxia-telangiectasia (A-T)<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/autism\/\">Autism<\/a><\/li>\n<li><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/cerebral-palsy-cp\/\">Cerebral Palsy (CP)<\/a><\/li>\n<li class=\"last\"><a href=\"https:\/\/pediatricbrainfoundation.org\/archive\/educate\/disorder\/sanfilippo-syndrome-mps-iii\/\">Sanfilippo Syndrome (MPS III)<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<p> <!-- \/.block -->\n  <\/div>\n<\/aside>\n<p>  <!-- \/#sidebar-second -->\n  <\/div>\n","protected":false,"raw":""},"excerpt":{"rendered":"<p>Get Educated Disease Directory Glossary Search by Keyword Search [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template_2.php","meta":{"footnotes":""},"class_list":["post-34","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - 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