{"id":228,"date":"2023-08-10T15:21:11","date_gmt":"2023-08-10T15:21:11","guid":{"rendered":"https:\/\/pediatricbrainfoundation.org\/archive\/bird-s-song-may-be-key-understanding-human-speech-disorders-ucla-scientists\/"},"modified":"2023-08-10T15:21:11","modified_gmt":"2023-08-10T15:21:11","slug":"bird-s-song-may-be-key-understanding-human-speech-disorders-ucla-scientists","status":"publish","type":"page","link":"https:\/\/pediatricbrainfoundation.org\/archive\/bird-s-song-may-be-key-understanding-human-speech-disorders-ucla-scientists\/","title":{"rendered":"A Bird\u2019s Song May Be Key to Understanding Human Speech Disorders, UCLA Scientists Report"},"content":{"rendered":"
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\u00ab Back to Scientific News<\/a><\/div>\n<\/section><\/div>\n
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A Bird\u2019s Song May Be Key to Understanding Human Speech Disorders, UCLA Scientists Report<\/h1>\n<\/section><\/div>\n
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\n Tuesday, March 30, 2004<\/span>  \u00b7  Posted by University of California- Los Angeles<\/a> <\/div>\n

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UCLA scientists report parallels between human speech and the song of a bird, findings that may contain clues to human speech disorders.<\/p>\n

The research by a team led by Stephanie White, UCLA assistant professor of physiological science, supports the theory that two genes shared by humans and songbirds, FoxP1 and FoxP2, may play a critical role in human speech, and speech disorders. \u00a0The study is published March 31 in the Journal of Neuroscience.<\/p>\n

“We examined the expression of FoxP1 and FoxP2 in embryonic human brains and found a striking correspondence between bird and human expression,” said White, a member of UCLA’s Brain Research Institute. \u00a0“The similar expression patterns suggest that songbirds can be studied to investigate neural mechanisms for vocal learning that may be parallel to those used by the human brain.<\/p>\n

“Our findings make it more likely that FoxP2 plays a critical role for learning speech and vocalization in both humans and the songbird,” she said. \u00a0“Understanding how FoxP1 and FoxP2 function in the songbird may reveal significant insights into human vocal learning and speech disorders.”<\/p>\n

FoxP2 is in the brain of the zebra finch in regions that control the learning of song, said White, who said that additional unknown molecules are likely to interact with the gene. \u00a0The UCLA study is the first to address whether FoxP2 is critical for learned vocalizations in other species.<\/p>\n

Male zebra finches learn to sing a courtship song that their female counterparts do not learn.<\/p>\n

White’s team detected increased level of the closely related gene, FoxP1, in “Area X” of the male zebra finch’s brain, a critical part of the bird’s song circuitry, and in two other song regions of the brain.<\/p>\n

“The finding that FoxP2 is expressed in the song circuit is exciting,” White said. \u00a0“We are getting a green light for studying the songbird to try to understand these genes.”<\/p>\n

FoxP2 may interact with FoxP1, and both genes may be critical for human speech, said White, whose team used molecular genetic techniques. \u00a0Increased understanding of these genes could potentially lead to new medications for speech disorders, she said.<\/p>\n

As a master gene regulates eye development, “FoxP2 may be a master gene involved in setting up structures required for facial control and vocalization,” White said.<\/p>\n

White’s team has shown that FoxP1 and FoxP2, while expressed early in life, stay on throughout the life of the songbird. \u00a0“This implies that these genes may be involved in the lifelong process of speech,” she said, adding that this idea is supported by evidence from a second team of researchers publishing separate findings in the same issue of the Journal of Neuroscience, based on studies of adult canaries, which sing seasonally.” \u00a0(The second team includes scientists from Germany’s Max Planck Institute for Molecular Genetics, Duke University, City University of New York, and the University of Pennsylvania. \u00a0They showed that FoxP2’s expression in Area X in canaries changes with the seasons, which is more evidence that FoxP2 is involved in vocal learning.)<\/p>\n

A study published in 2001 revealed a single mutation in FoxP2 in each member of a family in England with a severe speech disorder; many members of this family, over three generations, have the speech disorder, and each of these family members has the mutation, while those family members without the speech disorder do not have this mutation.<\/p>\n

If the human and songbird mechanisms underlying vocal learning are parallel, White would expect FoxP1 and FoxP2 would overlap in the same regions of the human brain. \u00a0“That turned out to be true; these genes are in analogous regions of the human brain and the zebra finch brain,” she said.<\/p>\n

Male zebra finches are sexually mature 100 days after birth, and have learned their courtship song by then, starting about 35 days after birth.
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“There are critical periods in song learning,” noted White, who joined UCLA’s faculty in 2000 after earned her Ph.D. at Stanford in neuroscience, and then conducted postdoctoral research at Duke University. \u00a0“If we can learn what FoxP1 and FoxP2 are doing during these periods, then we may be able to highlight key developmental moments in children, to make sure the genes function properly at critical periods.”<\/p>\n

While White’s team has not established the role FoxP2 plays in the male zebra finch’s learning of the courtship song, they have found that it is in the right part of the brain (the striatum) to play a critical role in the learning of vocalization.<\/p>\n

White and her team will continue research on FoxP1 and FoxP2, and the interaction between them, in the zebra finch and other birds. \u00a0She is interested in learning which genes are regulated by FoxP2, and which gene is required for vocal learning?<\/p>\n

White is interested in understanding social influences on learning, and on the neural changes that underlie learning.
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“Songbirds are perfect for these questions because they learn their courtship and territorial songs through social interactions with other songbirds,” she said. \u00a0“We want to understand the neural mechanisms that underlie vocal learning and see how social and environmental influences alter the learning, where that is happening in the brain, and what molecules are changing. \u00a0I’m very interested in human behavior, but humans are too complicated to study rigorously at the cellular and synaptic level.<\/p>\n

“Language is uniquely human, but it has components, such as the ability to create new sounds; the zebra finch does that. \u00a0It creates new sounds like instrumental music, and may do that using the same genes as humans.”<\/p>\n

There are approximately 9,000 species of birds, approximately 4,000 of which are songbirds. \u00a0There are more similarities between the human brain and the songbird’s brain than many people may realize, White said. \u00a0The term “bird-brain” may not be such a put-down after all.<\/p>\n


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human speech<\/a><\/div>\n
birds<\/a><\/div>\n
FoxP1<\/a><\/div>\n
FoxP2<\/a><\/div>\n
human vocal learning<\/a><\/div>\n
speech disorders<\/a><\/div>\n
zebra finch<\/a><\/div>\n
songbirds<\/a><\/div>\n<\/p><\/div>\n<\/div>\n