{"id":1102,"date":"2023-08-10T15:23:32","date_gmt":"2023-08-10T15:23:32","guid":{"rendered":"https:\/\/pediatricbrainfoundation.org\/archive\/mrna\/"},"modified":"2023-08-10T15:23:32","modified_gmt":"2023-08-10T15:23:32","slug":"mrna","status":"publish","type":"page","link":"https:\/\/pediatricbrainfoundation.org\/archive\/mrna\/","title":{"rendered":"MRNA"},"content":{"rendered":"
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Scientists discover tiny gene fragments linked to brain development and autism<\/a><\/h2>\n
\n Thursday, December 18, 2014<\/span>  \u00b7  Posted by University of Toronto<\/a> <\/div>\n

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Very small segments of genes called “microexons” influence how proteins interact with each other in the nervous system, scientists at the University of Toronto have found, opening up a new line of research into the cause of autism.<\/p>\n<\/div><\/div>\n<\/div>\n<\/article>\n

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It\u2019s not always the DNA<\/a><\/h2>\n
\n Thursday, November 13, 2014<\/span>  \u00b7  Posted by Washington University in St. Louis<\/a> <\/div>\n

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Damage to DNA is an issue for all cells, particularly in cancer, where the mechanisms that repair damage typically fail. The same agents that damage DNA also damage its sister molecule messenger RNA (mRNA), which ferries transcripts of the genes to the tens of thousands of ribosomes in each cell. But little attention has been paid to this damage.<\/p>\n<\/div><\/div>\n<\/div>\n<\/article>\n

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Zebrafish models for one-of-a-kind families<\/a><\/h2>\n
\n Tuesday, October 14, 2014<\/span>  \u00b7  Posted by Genetics Society of America<\/a> <\/div>\n

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Susan Brooks had reached a dead end.<\/p>\n

Brooks, a medical geneticist at Rutgers Robert Wood Johnson Medical School, was trying to diagnose a boy who had a genetic disorder she had never encountered before. The young patient showed delayed development, microcephaly, recurrent febrile illnesses, seizures, overall slow growth, and several minor craniofacial and limb malformations.<\/p>\n<\/div><\/div>\n<\/div>\n<\/article>\n

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New Information about Neurons Could Lead to Advancements in Understanding Brain and Neurological Disorders<\/a><\/h2>\n
\n Friday, October 10, 2014<\/span>  \u00b7  Posted by University of Missouri<\/a> <\/div>\n

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Neurons are electrically charged cells in the nervous system that interpret and transmit information using electrical and chemical signals. A neuron\u2019s electrical charge is determined by the flow of ions \u2013 charged atoms \u2013 in and out of the cell through pores, called ion channels. These pores open, allowing ions to rush in, and then shut. The neuron becomes charged and \u201csparks\u201d the next neuron in line.<\/p>\n<\/div><\/div>\n<\/div>\n<\/article>\n

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A novel mechanism for fast regulation of gene expression <\/a><\/h2>\n
\n Tuesday, March 18, 2014<\/span>  \u00b7  Posted by Washington University in St. Louis <\/a> <\/div>\n

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Findings show that mRNAS, which are typically thought to act solely as the template for protein translation, can also serve as regulatory RNAs, independent of their protein-coding capacity.<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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Protein Switch Dictates Cellular Fate: Stem Cell or Neuron<\/a><\/h2>\n
\n Thursday, February 13, 2014<\/span>  \u00b7  Posted by University of California, San Diego<\/a> <\/div>\n

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Humans with deficiencies in NMD have intellectual disability and often also have schizophrenia and autism. Therapies to enhance NMD in affected individuals could be useful in restoring the correct balance of stem cells and differentiated neurons and thereby help restore normal brain function.<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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Watching molecules morph into memories<\/a><\/h2>\n
\n Thursday, January 23, 2014<\/span>  \u00b7  Posted by Albert Einstein College of Medicine<\/a> <\/div>\n

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Researchers at Albert Einstein College of Medicine of Yeshiva University used advanced imaging techniques to provide a window into how the brain makes memories. These insights into the molecular basis of memory were made possible by a technological tour de force never before achieved in animals: a mouse model developed at Einstein in which molecules crucial to making memories were given fluorescent “tags” so they could be observed traveling in real time in living brain cells. <\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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Two-way traffic enable proteins to get where needed, avoid disease<\/a><\/h2>\n
\n Monday, November 25, 2013<\/span>  \u00b7  Posted by Georgia Regents University<\/a> <\/div>\n

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\u201cThe ability to reverse their tracks is important to their ability to eventually get where they need to go,\u201d Gonsalvez said. And location is really everything, because the proteins need to be expressed in a specific location to function correctly.<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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Made to Order at the Synapse: Dynamics of Protein Synthesis at Neuron Tip is Basis for Memory and Learning<\/a><\/h2>\n
\n Thursday, September 26, 2013<\/span>  \u00b7  Posted by University of Pennsylvania School of Medicine<\/a> <\/div>\n

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Knowing how proteins are made to order \u2013 as it were – at the synapse can help researchers better understand how memories are made. Nevertheless, the role of this \u201clocal\u201d environment in regulating which messenger RNAs are translated into proteins in a neuron\u2019s periphery is still a mystery.<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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