{"id":1094,"date":"2023-08-10T15:23:31","date_gmt":"2023-08-10T15:23:31","guid":{"rendered":"https:\/\/pediatricbrainfoundation.org\/archive\/minocycline\/"},"modified":"2023-08-10T15:23:31","modified_gmt":"2023-08-10T15:23:31","slug":"minocycline","status":"publish","type":"page","link":"https:\/\/pediatricbrainfoundation.org\/archive\/minocycline\/","title":{"rendered":"Minocycline"},"content":{"rendered":"
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‘Support cells’ in brain play important role in Down syndrome <\/a><\/h2>\n
\n Friday, July 18, 2014<\/span>  \u00b7  Posted by University of California-Davis <\/a> <\/div>\n

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Researchers from UC Davis School of Medicine and Shriners Hospitals for Children \u2013 Northern California have identified a group of cells in the brain that they say plays an important role in the abnormal neuron development in Down syndrome. After developing a new model for studying the syndrome using patient-derived stem cells, the scientists also found that applying an inexpensive antibiotic to the cells appears to correct many abnormalities in the interaction between the cells and developing neurons.
\n\u201cWe have developed a human cellular model for studying brain development in Down syndrome that allows us to carry out detailed physiological studies and screen possible new therapies,\u201d said Wenbin Deng, associate professor of biochemistry and molecular medicine and principal investigator of the study. \u201cThis model is more realistic than traditional animal models because it is derived from a patient\u2019s own cells.\u201d\n<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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Antibiotic brings some improvement in fragile X syndrome, reports JDBP<\/a><\/h2>\n
\n Sunday, April 8, 2012<\/span>  \u00b7  Posted by Wolters Kluwer Health<\/a> <\/div>\n

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This preliminary clinical trial shows small but significant benefits of minocycline in children with FXS. Other treatments for FXS are being investigated, including a new class of drugs called mGluR5 inhibitors. However, minocycline is the only targeted FXS treatment that is currently available by prescription. Because of its long history of use, the side effects and safety characteristics of minocycline are well known.<\/div>\n<\/p><\/div>\n<\/div>\n<\/article>\n

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